Antewise

Genetic Algorithm — Defect Skill Card in Slay the Spire 2

Updated 17 Oct 2026 Source Slay the Spire 2 card data (spire-codex.com API), 577 cards retrieved 17 October 2026 By
Data status: The facts on this page were checked against the source named above. Game values can still shift with a patch, so re-check anything that looks off.
Genetic Algorithm card art
Genetic Algorithm

Gain 1 Block. Permanently increase this card's Block by 3.

CharacterDefect
TypeSkill
RarityRare
Cost1 Energy
TargetSelf
Total Block1
Per Energy1.00 → 1.00 upgraded
KeywordsExhaust

Card text

Gain 1 Block. Permanently increase this card's Block by 3.

Upgraded: Gain 1 Block. Permanently increase this card's Block by 4.

Where it sits on the curve

Measured the same way as our efficiency tier list: total Block divided by Energy.

Genetic Algorithm produces 1.00 per Energy at base . That ranks it 56 of 56 of the 56 skills with a fixed cost. It sits in the top 2% on this measure.

The measure ignores everything that is not a number. Area damage, conditions and drawbacks are not priced in.

Other Defect cards at 1 Energy

Other cards with Exhaust

Where to go next

All 577 cards — the full table, filterable by character. Efficiency tier list — every measurable card ranked.

Rarity system explains how often this card appears. Enchantments covers the modifiers that can change it.

Frequently asked questions

What does Genetic Algorithm do in Slay the Spire 2?

Gain 1 Block. Permanently increase this card's Block by 3.

What does upgrading Genetic Algorithm change?

Gain 1 Block. Permanently increase this card's Block by 4.

How much does Genetic Algorithm cost?

1 Energy. It is a Rare Skill card.

Is Genetic Algorithm efficient for its cost?

It produces 1.00 Block per Energy, which ranks 56 of 56 among the skills that can be measured this way.

More Slay the Spire 2 guides

Sources

Figures and item data on this site are read from the game’s own reference wiki before publishing. Where a value could not be confirmed there, the page says so instead of filling the gap.