Antewise

Knowledge Demon — Boss in Slay the Spire 2

Updated 17 Oct 2026 Source Slay the Spire 2 enemy data (spire-codex.com API), 115 enemies retrieved 17 October 2026 By
Data status: The facts on this page were checked against the source named above. Game values can still shift with a patch, so re-check anything that looks off.
Knowledge Demon art
Knowledge Demon

Knowledge Demon is a Boss enemy with 379 (Ascension 399) HP in Slay the Spire 2.

TypeBoss
HP379 (Ascension 399)

Move set

MoveIntentDamageBlockHeal
Curse of Knowledge Debuff — — —
Slap Attack 17 / Asc 18 — —
Knowledge Overwhelming Attack 24 (8×3=24) / Asc 27 (9×3=27) — —
Ponder Attack + Heal + Buff 11 / Asc 13 — 30

Attack pattern

This enemy uses a conditional pattern , starting with CURSE_OF_KNOWLEDGE. The documented sequence is: CURSE_OF_KNOWLEDGE → SLAP → KNOWLEDGE_OVERWHELMING → PONDER → CurseOfKnowledgeBranch.

Where it appears

  • Act 2 - Hive — Boss

Quotes

  • “[object Object]”
  • “[object Object]”

Other Boss enemies

Where to go next

All 115 enemies — the full list. Card database lists the tools you bring to the fight.

Relics cover the passive bonuses that help you survive. Boss guide hub explains the named fights.

Frequently asked questions

What is Knowledge Demon in Slay the Spire 2?

Knowledge Demon is a Boss enemy with 379 (Ascension 399) HP. Its moves and attack pattern are listed below.

Where does Knowledge Demon appear?

It appears in: Act 2 - Hive.

More Slay the Spire 2 guides

Sources

Figures and item data on this site are read from the game’s own reference wiki before publishing. Where a value could not be confirmed there, the page says so instead of filling the gap.