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Potion of Doom — Common Potion in Slay the Spire 2

Updated 17 Oct 2026 Source Slay the Spire 2 potion data (spire-codex.com API), 63 potions retrieved 17 October 2026 By
Data status: The facts on this page were checked against the source named above. Game values can still shift with a patch, so re-check anything that looks off.
Potion of Doom potion art
Potion of Doom

Apply 33 Doom.

RarityCommon
Poolnecrobinder
TypeSingle-use consumable

Effect

Apply 33 Doom.

Potion data comes from the community-built Slay the Spire 2 compendium API and tracks the early-access build. Rarity decides how often a potion turns up, so the rare ones are worth saving for a fight you cannot otherwise win.

Other Common potions

Where to go next

All 63 potions — the full table. Relics cover the passive bonuses that last a whole run.

Card database lists the cards you might build around. Enchantments change the cards you keep.

Frequently asked questions

What does Potion of Doom do in Slay the Spire 2?

Apply 33 Doom.

How rare is Potion of Doom?

It is Common, in the necrobinder potion pool.

Should I hold or drink Potion of Doom?

Hold defensive potions for the turn that would kill you; drink offensive ones early if they remove a threat outright.

More Slay the Spire 2 guides

Sources

Figures and item data on this site are read from the game’s own reference wiki before publishing. Where a value could not be confirmed there, the page says so instead of filling the gap.