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Deadly Poison — Silent Skill Card in Slay the Spire 2

Updated 17 Oct 2026 Source Slay the Spire 2 card data (spire-codex.com API), 577 cards retrieved 17 October 2026 By
Data status: The facts on this page were checked against the source named above. Game values can still shift with a patch, so re-check anything that looks off.
Deadly Poison card art
Deadly Poison

Apply 5 Poison.

CharacterSilent
TypeSkill
RarityCommon
Cost1 Energy
TargetAnyEnemy

Card text

Apply 5 Poison.

Upgraded: Apply 7 Poison.

What it applies

  • Poison × 5

Other Silent cards at 1 Energy

Where to go next

All 577 cards — the full table, filterable by character. Efficiency tier list — every measurable card ranked.

Rarity system explains how often this card appears. Enchantments covers the modifiers that can change it.

Frequently asked questions

What does Deadly Poison do in Slay the Spire 2?

Apply 5 Poison.

What does upgrading Deadly Poison change?

Apply 7 Poison.

How much does Deadly Poison cost?

1 Energy. It is a Common Skill card.

More Slay the Spire 2 guides

Sources

Figures and item data on this site are read from the game’s own reference wiki before publishing. Where a value could not be confirmed there, the page says so instead of filling the gap.