Antewise

How to Beat the Queen in Slay the Spire 2 — 400 HP Boss

Updated 27 Oct 2026 Source Data parsed from slaythespire.wiki.gg (STS2 boss and monster data) and cached in src/data/ By
Data status: The facts on this page were checked against the source named above. Game values can still shift with a patch, so re-check anything that looks off.

The Queen is a 400 HP Act 3 Glory boss, but she is never alone. Her Torch Head Amalgam brings another 199 HP, so the room totals 599 HP — more than Aeonglass’s 535 on Ascension. She also hands you 99 stacks each of Frail, Weak and Vulnerable, which at that size simply means the rest of the fight.

That combination makes her the fight where “kill the boss” and “kill the add” give opposite answers, because her pattern actually checks whether the Amalgam died.

The fight at a glance

ActAct 3 — Glory
TypeBoss (with one minion)
HP400 (419 on Ascension 10)
Amalgam HP199 (211 on Ascension 10)
Room total599 (630 on Ascension 10)
OpeningPuppet Strings → You Are Mine
Biggest hitOff with Your Head, 3×5 = 15 (4×5 = 20)

Every move, with numbers

MoveIntentDamageAscensionEffect
Puppet StringsDebuff00Applies 3 Chains of Binding
You Are MineDebuff00Applies 99 Frail, 99 Weak, 99 Vulnerable
Burn Bright for MeBuff + Defend00Gains 20 Block
Off with Your HeadAttack3 × 5 = 154 × 5 = 20Five separate hits
ExecutionAttack1518Single hit
EnrageBuff00Gains 2 Strength

Her two opening turns — Puppet Strings and You Are Mine — deal zero damage. That is 2 free turns before the fight actually starts, and the largest single opportunity in the encounter: 400 HP is not that far away if you spend two turns setting up a scaling engine instead of blocking.

The 99-stack problem

You Are Mine applies 99 of each debuff. Weak at 99 reduces your attack damage for the rest of the fight; Frail at 99 does the same to your Block; Vulnerable at 99 means every hit she lands is amplified.

You cannot out-wait 99 stacks. Three practical consequences:

  • Artifact is close to mandatory. A single Artifact stack absorbs one application — but she applies all three at once, so you need three stacks to blank the turn entirely.
  • Do not build around a debuff cleanse you do not have. Plan for the debuffed numbers: assume your Block is worth 75% and your attacks 75%.
  • Kill speed matters more than usual. A long fight under 99 Vulnerable is a losing position, because every Torch Head Tackle at 18 becomes worse.

The Amalgam branch

The cached pattern is explicit: after the two opening debuffs she alternates between Burn Bright for Me if the Amalgam is alive and Off with Your Head if it has died.

StateHer moveWhat it means
Amalgam aliveBurn Bright for Me0 damage, 20 Block gained
Amalgam deadOff with Your Head15 damage (20 at Ascension) in 5 hits

So killing the 199 HP add does not calm the fight down — it switches her from a defensive turn to a 5-hit attack. Leaving it alive means eating Torch Head’s own rotation while she shields.

Torch Head Amalgam’s numbers:

MoveDamageAscensionNotes
Tackle1819Single hit
Tackle 21819Single hit
Beam8 × 3 = 248 × 3 = 24Three hits, no Ascension bump
Tackle 31415Single hit
Tackle 41415Single hit

Its Beam is the biggest number in the room at 24, and it does not scale on Ascension at all. That is the one turn where the add out-damages the boss.

Kill order maths

Two plans, two different totals.

PlanTotal damage neededDamage per turn over 8 turns
Queen only (ignore the add)40050.0
Queen + Amalgam59974.9
Queen + Amalgam at Ascension63078.8

Killing both costs 199 extra damage — roughly 50% more work — and switches the Queen into her attack pattern. In most decks the correct line is to leave the Amalgam alive, block its 24-damage Beam turns, and race the Queen’s 400. The add’s damage is smaller than the tempo cost of chewing through 199 HP while she gains 20 Block per alternating turn.

The exception is a deck with strong area damage. Hyperbeam (28 to all enemies, 36 upgraded) and Crash Landing (21 to all, 26 upgraded) hit both bodies for full value, which changes the maths: at 28 per Hyperbeam the add dies in 8 casts as a side effect of damage you were already dealing.

Turn-by-turn

TurnQueenAmalgamYour plan
1Puppet Strings (0)Tackle 18Free turn. Play powers. Block 18.
2You Are Mine (0)Tackle 2 18Second free turn. Take the debuffs, keep scaling.
3Burn Bright (20 Block)Beam 24Block 24. Do not dump attacks into her 20 Block.
4Off with Your Head (15/20)Tackle 3 14Block 20 at Ascension. Attack window on the add.
5Burn BrightTackle 4 14Block 14, build damage.
6Off with Your HeadTackle 1820 + 18 = 38 incoming at Ascension.

Two free opening turns is a real budget. If your deck can produce 50 damage per turn from turn 3, the Queen dies on turn 10 with the add still standing at roughly half HP.

What to bring

  • Three Artifact stacks or none. Partial Artifact is wasted here; three blanks You Are Mine entirely, which removes Frail, Weak and Vulnerable in one turn.
  • Per-hit Block. Off with Your Head is 5 hits of 3 (4 at Ascension) and Beam is 3 hits of 8, so Dexterity and Thorns scale well against both.
  • Scaling that does not need Vulnerable. With 99 Vulnerable on you the fight is short either way; Strength and Dexterity on your side are not affected by her debuffs.
  • One area attack if you have it. It converts the 199 HP add from a cost into a free by-product.

“Off with Your Head — Attack, 3 damage × 5 hits (4 × 5 at Ascension).” — STS2 boss data, slaythespire.wiki.gg

Where to go next

The boss table ranks every Act 3 fight by HP, and the monster index has the Amalgam’s full stat line. For the deck side, the cards database lists every area attack and its numbers, and the relics database is where the Artifact relics live. The Ascension page covers the +19 HP step.

Frequently asked questions

How much HP does the Queen have with her minion?

599 total: 400 for the Queen and 199 for the Torch Head Amalgam. On Ascension 10 that becomes 630 (419 + 211).

Can I block You Are Mine?

No. It is a debuff with 0 damage, so there is nothing to block, and 99 stacks cannot be waited out. Artifact is the only way to prevent it.

Does killing the Amalgam make the Queen easier?

Not directly. It changes her from Burn Bright for Me (0 damage, 20 Block) to Off with Your Head (15 damage, 20 at Ascension). You trade a defensive boss turn for an attack, and you spend 199 damage to get there.

Which is the bigger threat, Execution or Off with Your Head?

At Ascension, Off with Your Head at 4×5 = 20 beats Execution's 18, and it arrives as five hits, which is worse against flat Block. Both are smaller than the Amalgam's Beam at 24.

More Slay the Spire 2 guides

Sources

Figures and item data on this site are read from the game’s own reference wiki before publishing. Where a value could not be confirmed there, the page says so instead of filling the gap.