Spreading your stat points
The costliest mistake is feeding all three colours. Every weapon ends up weak and no scroll lands where it matters.
Pick a main stat and grow it. Let a second stat tag along only if your gear shares it.
Hoarding cells
Cells left in your pocket die with the run. Spend them at the Collector while you can.
A held cell is worth nothing. A banked cell buys an upgrade forever.
Fighting above your level
A deep biome with early gear is a quick death. Push forward only when your damage keeps pace.
Skip a fight if the numbers look wrong. A missed biome costs less than a lost run.
Ignoring curses and doors
A curse carried into a boss ends the run on one hit. Clear the curse first.
Timed doors tempt you to rush. Take them only when the route supports it.
Never rerolling mutations
A poor pick wastes a slot for the whole run. Swap or reroll mutations when a better one shows up.
Next: How a run works and Mutations guide.