Every building is a scripted gauntlet with a loot room at the end. Learning the shape of them turns looting from a gamble into a routine.
Follow the path
POIs route you through rooms toward the loot. Going the intended way triggers fewer surprises than breaking a wall in.
Sleepers and traps
Move slowly in the dark and listen. Most deaths inside buildings come from a zombie waking behind you, not from the fight ahead.
Carry discipline
Take the valuable and dense loot first. Drop a storage chest outside a large POI and clear it in two trips.