Enemies in Noita are less dangerous than the space around them. Learn the patterns and most fights are winnable.
Melee enemies
They close and punish panic. Back sideways, not into a corner. A wand with a short cast delay lets you fire while moving, which is the only way melee packs stop being scary.
Projectile enemies
Their damage lands after you move. Watch the aim, then step off the line. Do not stand in the spot a projectile was already pointed at.
Squads
When several spawn, retreat first. Clear them one at a time from distance. Trying to fight a squad in melee is how a full-health run ends in two seconds.
The real threat
Almost every death is a reaction you started: fire meeting oil, electricity meeting water, a bouncing spell returning. The enemy just finished the chain. Read the room before you shoot.
Learn the early walls
The Hiisi and Mina troops telegraph their shots; the Wand Mech is the first real damage check. Use cover and pop its turrets before trading. Once you can read those patterns, the deeper biomes stop feeling random.