Why there is no single best
Holocure has 99 weapons in the dataset: 47 unique main weapons (one per character, unusable by anyone else) plus basic weapons, Collabs and Super Collabs. Each character’s main weapon has 7 levels and cannot be enchanted, so your “best” weapon is decided the moment you pick a character.
Read the type, then the description
Every weapon has an attack category — Melee, Ranged, or Multishot — that tells you where it hits:
- Melee clears the swarm around you but leaves you exposed if surrounded.
- Ranged keeps chasers away while you kite.
- Multishot covers angles you are not facing and scales with projectile-count boosts.
The dataset records a type for 47 weapons; pair by type so your two slots answer close, far, and angled threats at once.
Use collabs to go beyond two slots
When two of your weapons hit max level they can fuse into a Collab, freeing a slot for a third pickup; Super Collabs fuse a collab with an item. The weapon synergy page explains the pairing logic, and the all-weapons page lists every weapon with its type.
How to use this page
Do not chase a single “S-tier” name. Pick the weapon whose type covers your starter’s gap, then deepen that pair with upgrades. See weapon types for the category definitions.