Arcana change the whole run
An Arcana is chosen before you start, not during the run. It bends the rules for the entire session rather than one weapon.
That makes the pick strategic. The right Arcana lifts the build you already wanted to play.
Match the Arcana to the plan
Some Arcana add raw power. Some change how weapons behave. Some hand you a starting bonus you build around.
Read the effect and ask what it rewards. An Arcana that rewards a style you dislike will fight your whole run.
A safe first choice
Beginners should pick an Arcana that adds damage or keeps them alive. Both reduce the early pressure without asking for a new playstyle.
The best early game build shows a loadout that pairs well with a simple damage Arcana.